Archive for September, 2009

GREEN TEA COMPONENT MAY HELP PRESERVE STORED PLATELETS, TISSUES

Monday, September 14th, 2009

Tampa, Fla. - In two separate studies, a major component in green tea, epigallocatechin-3-O-gallate (EGCG), has been found to help prolong the preservation of both stored blood platelets and cryopreserved skin tissues. Published in the current double issue of Cell Transplantation (18:5/6), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct, devoted to organ preservation and transplantation studies from Japan, the two complimentary studies have shown that EGCG, known to have strong anti-oxidative activity, can prolong platelet cell “shelf life” via anti-apoptosis (programmed cell death) properties and preserve skin tissues by controlling cell division. Dr. Suong-Hyn Hyon, lead author on both studies and associate professor in the Institute for Frontier Medical Sciences in Kyoto, Japan, says that EGCG, a green tea polyphenol, is a known anti-oxidation and anti-proliferation agent, yet the exact mechanism by which EGCG works is not yet known. However, some of the activity of EGCG is likely to be related to its surface binding ability.

>>>>>Read the full Press Release in our HeartVigor.com News Pages.

PIECE FROM CHILDHOOD VIRUS MAY SAVE TRAUMA LIVES

Monday, September 7th, 2009

Research presented Sept. 6 at European complement conference

A harmless shard from the shell of a common childhood virus may halt a biological process that kills a significant percentage of battlefield casualties, heart attack victims and oxygen deprived newborns, according to research presented Sunday, September 6, 2009, at the 12th European meeting on complement in human disease in Budapest, Hungary.

Introducing the virus’s shell in vitro shuts down what is known as the complement response, a primordial part of the immune system that attacks and destroys the organs and vascular lining of people who have been deprived of oxygen for prolonged periods, according to researchers at Children’s Hospital of The King’s Daughters (CHKD) and Eastern Virginia Medical School (EVMS), in Norfolk, Va.

The complement response kicks in after the victim has been revived, in what is known as a reperfusion injury. It does its work slowly but unrelentingly, killing soldiers, infants or heart attack victims over the course of days.

“To find a way to manipulate the complement system pharmacologically has been like a search for the Holy Grail,” said one of the lead researchers, Dr. Kenji Cunnion, an infectious disease physician at CHKD and an associate professor of pediatrics at EVMS.

While Cunnion and Neel Krishna, Ph.D., a pediatric virologist at CHKD and assistant professor of microbiology at EVMS, focus on pediatric research, they see clear military applications.

“The complement reaction is one of the major causes of death of the battlefield,” said Krishna. “By the time you get a victim to the hospital, it may be too late.”

Dr. L.D. Britt, M.D., MPH, Brickhouse professor and chairman of surgery at EVMS, agrees.

“Hemorrhagic shock is the leading cause of death in combat trauma and reperfusion injury plays a significant role both in increased mortality and increased brain damage,” said Britt.

>>>>>Read the full Press Release in our HeartVigor.com News Pages.